The study conducted by Josh LaBaer's research team in the Biodesign Institute at Arizona State University may one-day empower physicians with a more personalized approach to therapy as well as a new tool for the early screening of those that may ultimately become resistant to chemotherapy.
Drugs like tamoxifen have been part of the standard treatment regimen for many breast cancer patients and saved countless lives. Unfortunately, a very serious therapeutic problem can occur when the drug loses its potency over time as women develop a resistance to the drug treatment, and tumors reemerge.
Using a well-established cell model for breast cancer along with the LaBaer lab's extensive collection of fully sequenced human genes, the team performed the largest genetic screen of its kind-testing the ability of 500 regulatory proteins, called kinases, that have been implicated in tumor growth and drug resistance.
"Kinases turn out to be a key drug target and we wanted to take advantage of the large number of kinase genes available in the lab," said Laura Gonzalez, lead author of the study.
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