In the midst of the exciting University of Pennsylvania hair loss stem cell study, the U.K. Daily Mail decided to canvas the hair community and find some helpful, everyday tips to prevent baldness. The hope is that these suggestions will help hair loss sufferers maintain native hair while eagerly awaiting potential applications of the stem cell therapies.
The U.K. hair restoration experts, including Coalition hair transplant surgeon Dr. Bessam Farjo, provided the Daily Mail with some helpful tips and hints for maintaining a healthy head of hair and preventing hair loss. These suggestions include: avoiding harsh hair brushing, eating a balanced, cooked breakfast, avoiding petroleum-based hair waxes, relaxing, eating foods rich in iron (nuts, red meat, dark green vegetables, etc.), avoiding hair coloring, and refraining from smoking.
It’s important to point out that while many of these suggestions promote good total body and hair health in general, few have been proven as detriments to hair follicles or confirmed as true preventive measures. At this current juncture, the only proven, effective measures for stabilizing, preventing, and possibly reversing hair loss are medications like finasteride/Propecia, and minoxidil/Rogaine, and, in appropriate cases, surgical hair restoration. While we do encourage all hair loss sufferers to utilize proven methods and remain “cautiously optimistic” toward future breakthroughs, it is interesting and informative to review these types of suggestions and potentially pick up some new hair restoration tips and tricks!
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_______________ Blake – aka Future_HT_Doc
Editorial Assistant and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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I’ve been taking finasteride (1mg) for more than two years. I started on a regimen at the age of 20. I started taking it and, within two weeks, had absolutely no erections. I continued taking it for three months hoping the symptoms would go away.? The symptoms never went away and I stopped taking finasteride. After a 2 week sabbatical, the erections came back.? After a month-long abstinence, I started taking it again and the erections subsequently diminished. I continued taking finasteride for 14 months and could never get an erection. I then took another sabbatical. After 6 weeks, the erections came back. According to my dermatologist, I’ve receded from a Norwood 2, measured at the age of 20 to a Norwood 4, measured last month (2 months before my 23rd birthday). However, she noted that I have a very thick donor area.
Should I continue taking finasteride in light of my inability to maintain erections when I have the medication in my system and in light of the fact that it hasn’t reversed or stopped my hair loss? If I decide to get a hair transplant, would that mean I would have to continue a life-long therapy of finasteride? That would obviously mean a lifetime of no erections.
I hear a lot about not getting a hair transplant at a young age because your hair could potentially still recede and then you’d be chasing your hair loss–given you have enough donor hair. With that said, I also hear a lot about the possibility of cloning hair follicles and how it could be a viable option in the near future. Furthermore, a recent study came out about the possibility of awaking progenitor cells through the use of already present stem cells as the catalyst. My question is this: Although nothing is for certain, do you think it would be worthwhile for me to engage in a high density transplant operation which would result in a densely packed packed hairline and leave me with very limited donor hair? My only reason for doing so would be the possibility that should my hair continue to recede, I could remediate the progression of the hair loss through new potential advances in hair restoration.
Most hair restoration physicians highly recommend using Propecia (finasteride) combined with Rogaine (minoxidil) indefinitely after hair transplant surgery. This gives the patient the best opportunity to maintain the appearance of fullness over the long-term. However, if you discuss your desire to forgo finasteride, your hair transplant physician may recommend a more conservative approach conserving more follicular unit grafts to address further balding in the future.
Personally, if finasteride caused me to have no erections, I believe I would not take it. No matter how much I prefer having hair, the main reason I want hair is to be more confident and attractive to the opposite sex. If I were not able to act upon that desire then having hair for me is just not that important.
This is an exciting time for medical research. It seems that every week a new and interesting theory or potential hair loss treatment is announced. However, those of us who have already been dealing with androgenic alopecia for decades have seen many “10 years till the hair loss cure” predictions come and go. While I generally don’t consider myself an optimist, I do believe that young men your age can expect more effective hair loss treatments in your lifetime but I don’t think that reputable and ethical hair transplant physicians will plan surgeries that may depend upon as yet unavailable treatments to maintain their appearance in the future.
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David – aka TakingThePlunge Assistant Publisher and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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Technorati Tags: finasteride, hair loss, hair transplant, hair restoration, Propecia, Rogaine, minoxidil, follicular unit grafts, balding, hair loss treatment, androgenic alopecia, hair loss cure
This following article was written by recommended hair restoration physician Dr. William Lindsey and posted on our Hair Restoration Social Community and Discussion Forums.
Is it normal for a hair restoration surgeon to have his techs do most, if not all, of the grafting? I read that the physician I am considering does this.
Back in the days of minigraft hair transplantation, I probably placed about 75% of the grafts. When we switched to follicular unit grafting and increased the size of the cases, techs became more involved. Once we passed 1200 grafts, I essentially put in about half the grafts and the tech(s) did the others, with me finishing up.
Now, with bigger cases, and techs who really are quicker, more delicate, and more gentle than my 46 year old hands are, if I were having a hair transplant I’d want my techs to place my grafts preferential to me placing my own grafts if, of course, it were even possible.
The three key elements to a successful hair transplant are: a well thought out hairline design, dense placement and proper orientation of the slits? and gentle placement in an expedient fashion. The doctor should perform the first two and oversee and quality control the third item.
William H. Lindsey, MD, FACS McLean, VA
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David – aka TakingThePlunge Assistant Publisher and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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Due to issues associated with the traditional follicular unit transplantation/FUT “strip scar,” many hair restoration patients?seek advice on how to prevent hair transplant scars from stretching and treating the issue if stretching does occur. Recently, Coalition hair transplant surgeon Dr. William Lindsey shared helpful information regarding scar stretching with our Hair Restoration Social Community and Discussion Forums and helped address some of these concerns:
The golden window for pre-treating scar issues is from post-operative week 1 to 6. I ask all my hair transplant patients to come back for a free scar check at the one month mark and unfortunately less than 20% of patients follow through.
I do this because if the follicular unit transplantation scar looks good at a month post-operative, it is really rare, but not impossible, for the scar to act up later. And if it looks good, I tell folks to stop vitamin E or mederma – both of which, in my opinion, are useful modalities for pre-treating and possibly preventing scar stretching if it occurs.
Bottom line, if you are prone to scar issues, make sure your hair restoration physician is involved with the post-operative care.
Dr. William Lindsey _______________ Blake – aka Future_HT_Doc
Editorial Assistant and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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This following article was written by recommended hair restoration physician Dr. William Lindsey and posted on our Hair Restoration Social Community and Discussion Forums.
I’m considering a hair transplant and I prefer follicular unit extraction (FUE) because I like to wear my hair very short. However, from the research I’ve carried out, I can’t seem to find any evidence that this procedure actually works for black men. There are plenty of before and after photos of FUE patients available on the Net but I haven’t seen any featuring black men. Can anyone give some information about the availability of FUE for black patients?
In my opinion, it’s harder to perform follicular unit extraction on curly African hair than with straight-rooted (non-black) hair. However, I’ve now done 6 FUE cases on? black patients and each hair transplant has been easier than the previous one.
The last one we did in early December was super easy and, coincidentally, he was also our very first black FUE patient. His post-op photos can be seen in this discussion thread, FUE into Black Male Donor Scar by Dr. Lindsey McLean VA. Our first case on him took all day to harvest about 100 follicular unit grafts. We performed another FUE on him in May and it took all day to get 300 grafts. Last month we were able to extract 723 grafts by 11am. Now, either he got easier or we got better.
Anyhow, I’d never say it was a “breeze” to perform this type of surgical hair restoration on patients of African descent but it’s a viable option for those balding guys that would like to wear their hair very short.
William H. Lindsey, MD, FACS McLean, VA
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David – aka TakingThePlunge Assistant Publisher and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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Technorati Tags: hair transplant, follicular unit extraction, FUE, follicular unit grafts, hair restoration, balding
Since the advent of the internet, more and more activities that used to take place on a “face-to-face” basis are now being conducted online. Like many other fields and industries, hair transplantation has evolved as well, and the use of “online consultations is now a realistic and viable option for hair loss sufferers.
However, one of the most important aspects of these online/digital hair restoration consultations is the availability of high-resolution photographs to be reviewed by consulting hair restoration physicians. Furthermore, being able to properly document and photograph personal hair loss is a useful tool for all balding patients looking to understand the severity of the condition and how to move forward.
Because of this, “Jotronic,” a senior member at our Hair Loss Forum and Social Community and??and a consultant for Coalition hair transplant surgeons Dr. Hasson and Dr. Wong, created a video explaining and demonstrating how to take, present, save, and send high-quality hair loss photographs:
I’ve finally taken the time to put together a video on how to take proper photos to send to your clinic of choice. It is a subject I’ve spoken about for years. I get so many pictures from people wanting an evaluation that are out of focus, taken in bad lighting etc. that I decided that I should do what I can to inform people how important good photo taking is.
Jotronic
Please visit the discussion topic How to Take Hair Transplant Photos to view the video and learn how to take compelling hair restoration photographs! _______________ Blake – aka Future_HT_Doc
Editorial Assistant and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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Technorati Tags: hair transplantation, online consultations, hair loss sufferers, digital hair restoration consultations, hair restoration physicians, hair loss, balding patients, Hair Loss, hair transplant, hair loss photographs
In an exciting new study conducted at the University Of Pennsylvania School of Medicine, researchers concluded that male pattern baldness may be caused by an inactivation of stem cells. For years, scientists and hair restoration physicians theorized that a depletion of stem cells or an abnormality of healthy stem cells causes genetic baldness. In this newest study, researchers seem to have clarified these differing ideas.
In the experiment, the research team analyzed scalp affected by male pattern baldness compared to healthy scalp and were surprised to find that the number of stem cells located within these two regions was identical. After some analysis, the team realized the difference between the bald scalp and healthy scalp wasn’t the total number of stem cells, but the number of one specific time of stem cell called a progenitor cell.
Progenitor cells are stems cells which have been activated and converted to a healthy, functional state. The lack of progenitor stem cells in the balding scalp seems to indicate that the hair loss is a result of the inactivation and improper conversion of certain stem cells into the progenitor cell state.
The researchers then isolated and extracted an analogous progenitor cell in mice, which, when removed and injected into a specialized mouse without an immune system, were able to grow a hair follicle. From here, the researchers plan on analyzing these types of progenitor cells in female hair loss sufferers, and also theorize that this type of therapy could be used in a type of injectable, stem cell based serum or topical treatment in the future.
Although this progress is quite exciting, it’s always good to keep “miracle cures” in perspective and remain cautiously optimistic toward future applications. The biggest breakthrough inherent in this study, in my personal opinion, is the idea that baldness is caused by stem cell inactivation/improper progenitor activate and not by a lack of stem cells in the scalp. By figuring this out, researchers have made a big step toward honing in on an accurate stem cell based therapy.
_______________ Blake – aka Future_HT_Doc
Editorial Assistant and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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Laser therapy for hair loss remains a hot topic amongst hair restoration professionals and patients alike. While some see it as an effective method of treating androgenic alopecia and other forms of hair loss, others condemn it as quackery. This discrepancy may be due in part to the ambiguous marketing of products like the HairMax LaserComb.
While the HairMax laser comb device was found by the FDA to be safe based on its “substantial equivalence” to previously approved laser light therapy devices and thus “cleared” (not “approved”), it was unclear to what extent the FDA reviewed or cleared it based on its effectiveness in treating balding. However, it appears that this device and similar devices are often touted as being “FDA approved” to treat thinning hair.
With very little verifiable data and mostly anecdotal information to support or refute its efficacy, this debate is likely to continue for awhile.
To read more about the experiences of our members and add your own thoughts and comments, join the discussion thread, Laser Hair Restoration, Fact or Fiction? started by Hair Restoration Forum member “jzachary”.
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David – aka TakingThePlunge Assistant Publisher and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
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Balding men and women who underwent surgical hair restoration in the early years, prior to the advancement of follicular unit transplantation (FUT) and follicular unit extraction (FUE), were often left with unnatural and unsightly “hair plugs“. These larger grafts created an effect much like that of doll’s hair. Today, many of these patients are seeking to revise or even remove these older grafts completely.? Below, recommended hair transplant surgeon?Dr. Michael Beehner discusses the process of removing plugs:
One thing to bear in mind is that, regardless of what size punch you use in cutting these old hair transplant grafts out, with a single pass procedure there will always be some hairs that don’t get removed and still grow. Therefore, it always requires a second smaller pass, usually with a smaller punch, to get complete eradication of the hairs.
The patient below has very fair Irish/English scalp skin and the redness you see will most certainly be better at the one year point. However, I think, cosmetically, it will look best with some dermabrasion or laser resurfacing to give it an “even”, homogeneous look, which is what he is after.
Mike Beehner, M.D.
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David – aka TakingThePlunge Assistant Publisher and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
Get Proven Hair Loss Treatments at the Best Prices by visiting our new Online Hair Loss Product Store
Technorati Tags: Balding, hair restoration, follicular unit transplantation, FUT, follicular unit extraction, FUE, hair plugs, hair transplant
One of the questions most often asked by hair loss sufferers on our Hair Restoration Forum and Social Network is how to care for your newly transplanted hair in the days and weeks following hair restoration surgery. While it is always best to follow your hair transplant surgeon’s aftercare advice, there are some basic rules of thumb to be aware of.
Do not bump your head the first few days after a hair transplant.Do not pick at the scabs on your head with your nails.Avoid extreme sweating for the first 10 days post-op.Sleep at an incline for the first 7 to 10 days.Walking can minimize swelling the first 7 days post op.Avoid exposing your scalp to the sun for the first 3 months after surgery.
To learn more about caring your hair transplant or to add your own post-operative regimen, you are encouraged to join the discussion, How Gentle Do You Need Need to be Recipient Area After a Hair Transplant? —-
David – aka TakingThePlunge Assistant Publisher and Forum Co-Moderator for the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the Hair Restoration Forum
Get Proven Hair Loss Treatments at the Best Prices by visiting our new Online Hair Loss Product Store
A solar-powered car designed and built by the students of the University of New South Wales has become the world's fastest solar vehicle.
The car, designed and built by UNSW students, smashed the world solar car speed record at the HMAS Albatross navy base airstrip in Nowra, travelling at more than 88km/h.
The speed was significantly faster than the previous record of 79km/h. The milestone is for cars powered exclusively by silicon solar cells. IVy normally uses its cells to charge a 25kg battery, but this was removed for the record attempt.
?We broke the record at 10.32 this morning,? said Sunswift project manager Daniel Friedman. ?The Guinness World Book of Records adjudicators were on hand, so it?s all official. We?ve even been handed our certificate.?
Friedman said the team was excited that the car performed so well. ?We were expecting to get our peak sun at noon, so the fact we broke the record so early was a great result.
?We hope the news will spur a lot more interest in solar energy and the debate about renewable energy technology,? he said.
Sunswift IVy is designed and built by UNSW students. While students are also usually the drivers of the carbon-fibre race vehicle, professional racing driver Barton Mawer and Craig Davis, from electric car firm Tesla?s European operations, were drivers for this attempt.
"We were confident ? we only needed a little bit of sunshine and that was enough,? Mawer said.
Partial hearing loss could be effectively addressed by a new hybrid cochlear implant, it has been shown.
The device aims to restore hearing for individuals with high-frequency hearing loss and functional low-frequency hearing.
This group of patients doesn?t meet the criteria for conventional cochlear implants because they have near perfect residual hearing in low pitches that allows them to perform well on tests used to determine candidacy for traditional implants. However, their hearing in high pitches is so poor that a hearing aid is not helpful, making them ideally suited for the hybrid implant which addresses both issues.
Northwestern Memorial Hospital is one of nine centers in the U.S that are participating in a study investigating the effectiveness of the new cochlear implant.
?We are hopeful that the hybrid cochlear implant will provide a subset of people who were previously not candidates for an implantable device the opportunity to test the device to determine if they can experience sound again,? said Northwestern Medicine neurotologist Andrew Fishman, MD, principal investigator of the study, staff in the departments of otolaryngology and neurosurgery at Northwestern University?s Feinberg School of Medicine, and Mr. Groves? cochlear implant surgeon. ?The potential for patients with a significant amount of residual hearing, but a large amount of high-frequency hearing loss, to have an alternative to hearing aids would be a great improvement to what is currently available.?
Cochlear implants were FDA approved in 1984 as a treatment option for restoring hearing in people with severe and profound hearing loss. The surgical implant system is designed to stimulate the auditory nerve by bypassing damaged parts of the ear. A small battery-operated mini ?computer? and microphone are worn on the outside of the ear and convert sounds into electric signals. The signals are then transmitted to implant electrodes in the cochlea, which stimulate the nerve endings so sound can be perceived by the brain.
An accurate new DNA blood test could almost eliminate the need for risky invasive tests for Down's syndrome, according to a research published.
Down's syndrome, a major developmental disorder also called trisomy 21, occurs in around one in every 800 live births.
Pre-natal diagnosis mainly entails sampling fluid, drawn by a needle, from the amniotic sac enveloping the foetus. Another technique is called chorionic villus sampling, and entails taking a sample of placenta.
Both techniques, though, carry a roughly one-percent risk of miscarriage, which is why they are reserved for older mothers-to-be and other women deemed at risk.
Researchers led by Dennis Lo, a professor at the Chinese University of Hong Kong, carried out the first large-scale investigation into new DNA technology which sequences telltale foetal molecules in maternal blood.
The test was carried out among 753 women who were all in the high-risk category.
Eighty-six of them were found to be carrying a foetus with Down's. The test detected this with 96.6 percent accuracy and did not deliver any "false negatives," meaning that it wrongly said a woman did not have a Down's foetus.
"The sequencing test could be used to rule out trisomy 21 among high-risk pregnancies before proceeding to invasive diagnostic testing," says the study, published online by the British Medical Journal (BMJ).
A vaccine for the painful disease called shingles is highly effective, which can lower the risk of developing the condition by 55 percent, a study said Tuesday.
Nearly one in three people risk acquiring shingles, also known as herpes zoster, at some point in their lives.
Shingles can linger for weeks or years, causing blistering rashes and body pain mainly in older adults and those with weak immune systems.
A vaccine was approved by the US Food and Drug Administration in 2006 but only about 10 percent of the US population is currently taking it, experts said.
The study, published in the Journal of the American Medical Association, took a retrospective look at health data from 300,000 people in California from 2007 to 2009.
By comparing how many people got shingles in vaccinated versus unvaccinated populations, researchers determined that the vaccine resulted in a 55 percent lower risk.
The risk appeared to stay lower in populations over age 75, a group that was previously found by a clinical study of 38,000 patients not to glean much benefit from the vaccine.
"Our study shows the vaccine has the potential to prevent tens of thousands of cases of shingles, a painful, lingering disease," said study lead author Hung Fu Tseng, a research scientist with the Kaiser Permanente Department of Research and Evaluation in Pasadena, California.
"We suggest clinicians follow the CDC's (Centers for Disease Control and Prevention) recommendations to talk to their patients about the option of vaccination against this serious condition."
A Canadian company has created 3D glasses that can detect your mood and will adjust what you're watching according to how you're feeling.
Canadian digital innovations company InteraXon unveiled its latest products incorporating Thought Controlled Computing-a technology that lets users control a digital interface using simply the power of their concentration.
Their creations include thought-controlled 3D glasses that tests a person's ability to focus their mind for an extended period of time, reports Fox News.
"We've developed a simple sensor that sits on your forehead and reads your brainwaves," said InteraXon CEO Ariel Garten.
"It's just like a heart monitor that can read your heart rate. And the software translates your brainwave data and uses it to control your virtual world," said Garten.
He called it a brain/computer interface, or BCI, and InteraXon builds it into a simple, lightweight headband.
"It (3-D glasses) gives you the ability to watch a movie or televised content, and it knows the state that you're in, whether it be scared, excited, or bored," said Garten.
The editor of The Lancet, Dr Richard Horton, has apologised for naming a drug-resistant superbug after New Delhi.
The Lancet journal revealed in August the discovery of a superbug that could pose a global threat like Severe Acute Respiratory Syndrome (SARS) or human swine flu.
Researchers named the enzyme "New Delhi metallo-beta-lactamase 1 (NDM-1)" as some victims had recently travelled to India for medical treatment and cosmetic surgery -- but health experts in India were furious at the tag.
"It was an error of judgement," Richard Horton, editor of the London-based Lancet told reporters on Tuesday during a visit to Delhi. "We didn't think of its implications for which I sincerely apologise."
The name "unnecessarily stigmatised a single country and city" and should be changed by researchers, he added.
Indian doctors complained the name incorrectly suggested New Delhi was the origin of the bug -- and some politicians saw a conspiracy designed to scupper the country's booming health tourism industry.
The government health ministry angrily dismissed The Lancet's report as exaggerated and unfair, and publicly complained about the name.
The NDM-1 gene was first identified in 2009 by Cardiff University's Timothy Walsh in two types of bacteria -- Klebsiella pneumoniae and Escherichia coli -- in a Swedish patient admitted to hospital in India.
After The Lancet article, cases were reported in Canada, the United States, Belgium, the Netherlands, Austria, France, Germany, Kenya, Australia, Hong Kong and Japan.
Horton said he stood by the study's research.
India has been criticised in the past for having a loose policy on the use of antibiotics, with the result that they are over-prescribed and over-used to the point where resistant strains become more common.
Bottles rockets can cause serious eye injuries in children, often leading to permanent loss of vision, according to a report that will appear in the May print issue of Archives of Ophthalmology, one of the JAMA/Archives journals.
Of the estimated 9,200 emergency department admissions resulting from fireworks-related injuries each year, about 1,400 cases involve the eyes, according to background information in the article. A disproportionate number of these injuries are caused by bottle rockets. Bottle rockets are about half the size of a normal firework and consist of three main parts: an explosive-filled core, a nose cone that guides the fireworks' flight and a guide stick, which stabilizes the rocket. "Injuries may result from direct high-velocity contact with the intact rocket, from parts of the rocket that may break off during flight or from neighboring debris propelled by the force of the rockets' combustion," the authors write.
Mehnaz Kahn, M.S., and colleagues at Vanderbilt University Medical Center, Nashville, report on 11 eyes in 10 patients (eight boys and two girls) age 18 or younger who were seen for eye injuries caused by bottle rockets between 2006 and 2009. Eight of the 10 patients were injured within a month of July 4; eight were launching bottle rockets at the time of injury and two were bystanders. None were using protective eyewear at the time.
Of these, injuries included defects in the epithelium lining the cornea (seven eyes), bleeding in the front of the eye (six eyes), traumatic inflammation of the iris (two eyes), iridodialysis or a tear of the iris (four eyes), cataract (four eyes), retinal dialysis or a type of retinal tear (one eye) and bleeding into the eye's vitreous fluid (two eyes).
An implant that releases the medication dexamethasone within the eye appears to be safe and effective for the treatment of a type of eye disease namely uveitis (swelling and inflammation in the eye's middle layer), according to a report.
"Uveitis refers to a group of intraocular inflammatory diseases that cause 10 percent to 15 percent of blindness in the developed world," the authors write as background information in the article. "Despite advances in immunosuppressive treatments, corticosteroids remain the mainstay of therapy." However, some patients cannot tolerate or do not respond to systemic corticosteroids, in part because the medications do not cross the blood-retinal barrier. Eye drops containing corticosteroids are effective only for anterior uveitis, closer to the front of the eye. Injections of corticosteroids directly into the eye have been effective in forms of intermediate or posterior uveitis, but require repeated treatments every two to three months and are associated with cataracts and other adverse effects.
To address these issues, an intravitreal (within the vitreous fluid of the eye), bioerodible, sustained-release implant has been developed to deliver a glucocorticoid medication, dexamethasone, to the back of the eye chamber. Careen Lowder, M.D., Ph.D., of the Cleveland Clinic Cole Eye Institute, and colleagues in the Ozurdex HURON Study Group conducted a 26-week randomized controlled trial involving 229 patients with intermediate or posterior uveitis. A total of 77 patients received an implant with a 0.7-milligram dose of dexamethasone, 76 received an implant with a 0.35-milligram dose and 76 underwent a sham procedure which followed the same protocol but used a needleless applicator.
Researchers from University of California have recently discovered that a protein Nrf2, plays a vital role in some antioxidant therapies and also promotes atherosclerosis - clogging of arteries. Physicians could soon be able to point out why some antioxidant therapies are not yielding the desired effects. br> The protein, Nrf2, has been thought to be an important drug-therapy target for diseases such as cancer because it can induce chemo-preventive activity, leading to the release of numerous antioxidant and anti-inflammatory genes and enzymes.
Earlier, researchers had reasoned that Nrf2, with its potent ability to boost antioxidants, might also be useful in combating the cell and tissue damage, or oxidation that leads to atherosclerosis.
However, UCLA scientists found that while Nrf2 boosted antioxidant properties in an animal model, it also increased the development of atherosclerosis by raising plasma cholesterol levels and cholesterol content in the liver.
According to them, this is the first study to document these additional effects on cholesterol metabolism in tandem with plaque formation in the arteries.
"The atherosclerosis-producing factors were greater than the antioxidant benefits. The development of novel antioxidant therapies is quite important, and this research may help shed light on why treatments affecting this protein may not be as effective as we thought," said principal investigator Jesus Araujo.
Haiti cholera outbreak that has claimed 3,651 lives has not peaked, the World Health Organisation said Tuesday.
"We think that the peak has not been reached," said Fadela Chaib, WHO spokeswoman, of the deadly disease that has also infected 171,304 people.
"The peak has not been reached because it would require the mortality rate to drop to less than one percent from 2.2 percent at the moment. That would take several weeks," she said.
"There will be certainly many more cases of cholera in Haiti, it's certain. But what is sure is that fewer people will die," added the spokeswoman, noting that the mortality rate had already been cut from nine percent late last year.
Chaib also pointed out that in certain rural areas, more than 100 new cases of cholera were still being detected every day.
The spokeswoman said that the UN health agency had trained more than 500 health experts to deal with the cholera outbreak.
"We are continuing to mobilise experts to the most affected zones," she added, saying that "very significant challenges" remain in the impoverished Caribbean nation.
The epidemic, which began in October 2010, spawned deadly anti-UN riots in November as some turned their anger on peacekeepers from Nepal accused of bringing the disease into the country.
The human brain undergoes changes in adolescence that inhibits fearful experiences learned in childhood, said a study released Monday. These brain changes could explain the fact why teenagers act so brashly at times.
Scientists studied the fear responses of mice for clues about how adolescents would react to situations that resembled prior experiences that involved pairing of electric shocks and tonal noises.
When they compared how adolescent mice showed a freeze reaction, compared to younger and older mice, they found that the teenagers did not freeze at the same rate, and that they were suppressing their reactions to contextual fear.
An examination of the brain activity in the adolescent mice showed that the two areas of the brain associated with processing experiences of fear -- the basal amygdala and the hippocampus -- were exhibiting lower levels of activity.
It wasn't that the teen mice failed to learn to be afraid, it was just that their brains weren't sending the same signals as the brains of baby or adult mice.
"Suppression of contextual fear and associated synaptic activity occurs as the mice transition into adolescence," said the study published in the Proceedings of the National Academy of Sciences.
"This temporary suppression of contextual fear was associated with blunted synaptic activity in the basal amygdala and decreased... signaling in the hippocampus," it said.
"Although contextual fear memories were not expressed during early adolescence, they could be retrieved and expressed as the mice transitioned out of adolescence."
Aggressive Care Increases Medicare Costs in Advanced Dementia.tabnews{padding: 8px 0;margin-left: 0;margin-top: 1px;margin-bottom: 0;font: bold 12px Verdana;list-style-type: none;text-align: left; /*set to left, center, or right to align the menu as desired*/}.tabnews li{display: inline;margin: 0px;}.tabnews li a{text-decoration: none;position: relative;z-index: 1;padding: 8px 7px;margin-right: 3px;border: 1px solid #778;border-top: 3px solid #000080;color: #2d2b2b;background: #f0f8ff; height:31px;background-position: 0 .0em;}.tabnews li a:visited{color: #2d2b2b;}.tabnews li a:hover{text-decoration: underline;color: #2d2b2b;}.tabnews li a.selected{ /*selected main tab style */position: relative;top: 1px;}.tabnews li a.selected{ /*selected main tab style */background: #ffffff; border-bottom-color: white;}.tabnews li a.selected:hover{ /*selected main tab style */text-decoration: none;}.tabcontent{display:none;}.dbfl{display:block; float:left;}#latestOn{ display:block; float:left; width:290px; background-color:#DADADA; padding:5px;}#latestOn .tabs{ display:block; width:290px; background-color:#DADADA; }#latestOn .tabs a.dAct{display:block; float:left; padding:5px 2px; border-left:3px solid #DADADA; border-right:3px solid #DADADA; border-bottom:3px solid #DADADA; background-color:#E7E7E7; font-size:10px; font-weight:bold; text-decoration:none; color:#333333; }#latestOn .tabs a.active{display:block; float:left; padding:5px 2px; border-left:3px solid #FFFFFF; border-right:3px solid #FFFFFF; border-bottom:3px solid #FFFFFF; background-color:#FFFFFF; font-size:10px; font-weight:bold; text-decoration:none; color:#000080; }#latestOn .contentDiv{display:block; float:left; background-color:#FFFFFF; width:290px; padding-bottom:5px;}#latestOn .thumbDiv{ display:block; float:left; width:140px; padding-left:5px; padding-top:10px;}#latestOn .thumbDiv img{ display:block; float:left; padding:1px; border:1px solid #CCCCCC; margin-right:5px;}.dheight{ height:1%;}.dheight:after{ height:0; content:''; display:block; clear:both;}#SearchOn1{ display:block; float:left; width:665px; background-color:#C2E1F6; padding:5px;}#SearchOn1 .tabs{ display:block; width:665px; background-color:#C2E1F6; }#SearchOn1 .tabs a.dAct{display:block; float:left; padding:5px 2px; border-left:3px solid #C2E1F6; border-right:3px solid #C2E1F6; border-bottom:3px solid #C2E1F6; background-color:#C2E1F6; font-size:10px; font-weight:bold; text-decoration:none; color:#333333; }#SearchOn1 .tabs a.active{display:block; float:left; padding:5px 2px; border-left:3px solid #FFFFFF; border-right:3px solid #FFFFFF; border-bottom:3px solid #FFFFFF; background-color:#FFFFFF; font-size:10px; font-weight:bold; text-decoration:none; color:#000080; }#SearchOn1 .contentDiv{display:block; float:left; background-color:#FFFFFF; width:665px; padding-bottom:5px;}function fnsearch1(){ tmpcatid=document.search1.ncategoryid.value;tmpkeyword=document.search1.keyword.value;document.search1.action="http://www.medindia.net/news/newsday_list.asp?ncategoryid=" +tmpcatid +"&keyword=" +tmpkeywordreturn true;} Medindia On Mobile About UsPortfolioPressCareersSitemapAdvertiseContact Us Make this your Homepage @import url(http://www.google.com/cse/api/branding.css); Custom Search .backgroundHide{display:none;position:fixed;_position:absolute;height:100%;width:100%;top:0;left:0;background:#000;z-index:1;} Register Sign In Sign In Using Facebook HOME NEWS Latest Health News Popular News Topics Health News Central News Photo Gallery Special Reports Latest Press Releases Health Press Releases News Archive A-Z Disease News News Index
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The study examined Medicare expenditures for 323 nursing home residents with advanced dementia in 22 facilities in the Greater Boston area as part of the Choices, Attitudes, and Strategies for Care of Advanced Dementia, or CASCADE, study. According to the findings, the largest proportion of Medicare expenditures was for hospitalizations (30.2%) and hospice (45.6%). Medicare expenditures rose by 65 percent in each of the last four quarters before death, primarily due to an increase in both acute care and hospice services. Acute care costs were lower among residents who had either a Do Not Hospitalize (DNH) order, lived on a special care dementia unit, or did not have a feeding tube.
"Our study demonstrates that a large proportion of Medicare expenditures in advanced dementia are attributable to acute and sub-acute services that may be avoidable and may not improve clinical outcomes," says senior author Susan L. Mitchell, M.D., M.P.H., a senior scientist at the Institute for Aging Research.
An additional 10 percent of Medicare expenditures were for care in a rehabilitation facility after hospitalization. Dr. Mitchell calls the benefits of skilled nursing or rehabilitative care for these patients "questionable," given that most of them are totally physically functionally and cognitively impaired. 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A large proportion of medicare expenditures for nursing home residents with end term dementia, a terminal illness, is spent on aggressive treatments that may be avoided, according to a study by the Institute for Aging Research, an affiliate of Harvard Medical School. 
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Posted By :??PAR84??on??Mon, Nov 29 2010The article's title is very misleading, given that it's about a trial in animals...Under :??Memory Problems in Alzheimer Patients Treated by New Gene Therapy??Support Group :??Alzheimer's Disease??No.?of?Posts:??2??Views:??138???Reply 
Posted By :??medindia??on??Mon, Nov 29 2010A new gene therapy that was successful in treating memory problems in mice with...Under :??Memory Problems in Alzheimer Patients Treated by New Gene Therapy??Support Group :??Alzheimer's Disease??No.?of?Posts:??2??Views:??138???Reply 
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DNA Blood Test Could End Risky Tests For Down's Syndrome 
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India's Mobile Healthcare 
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